A skin biopsy is a procedure in which a doctor cuts and removes a small sample of skin to have it tested. This sample may help your doctor diagnose diseases such as skin cancer, infection, or other skin disorders.

The management of skin diseases requires a pertinent diagnosis, which in many occasions constitutes an intricate process. Skin biopsy is an established diagnostic procedure which connects clinical diagnostic methodology with the invisible to the unaided eye microscopic field of skin pathology. Taking under consideration the potentials and limitations of optical microscopy and the indications of performing an invasive technique, dermatologists often rely on skin biopsy for enhancing their diagnostic abilities. The aim of this study was to investigate the favourable clinical diagnoses set by dermatologists when performing skin biopsy, the diagnoses reached by the dermatopathologists after microscopic examination, as well as the relationship between them, and finally to comment on the instances that skin biopsy fails to fulfill the diagnostic task.